The area that is now Pittsburgh, like most of North America, was inhabited by Native Americans for centuries. Some of the earliest artifacts of human settlement are found at the Meadowcroft Rockshelter located about an hour west of the city and date back 16,000 years!
Fast forwarding to western settlements, we jump to the 1700s when European colonists came into the region. Battles between the French and British ensued and control of the region swapped hands a few times. The British ultimately won, and the area around Fort Pitt, now known as Pittsburgh, grew from there.